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中文摘要: 在4-二甲氨基吡啶（DMAP）的催化下，天然高分子海带多糖（Lam）与甲基丙烯酸缩水甘油酯（GMA）发生亲核取代反应，制备出一种新型水溶性生物可降解交联剂——甲基丙烯酸缩水甘油酯接枝海带多糖（Lam-GMA）。以Lam-GMA为交联剂，与丙烯酰胺（AM）单体共聚制备水凝胶。在生理条件与脂肪酶的作用下，对凝胶的溶胀特性和降解行为进行研究。以牛血清白蛋白（BSA）为模型高分子药物，包埋在水凝胶中，研究其降解释药行为。结果表明，GMA接枝到Lam链的反应转化率很高，并且接枝率可控；交联剂用量越大，水凝胶降解所需时间越长；随着水凝胶的降解BSA缓慢释放。
中文关键词: 海带多糖 甲基丙烯酸缩水甘油酯 生物可降解交联剂 水凝胶 药物控释
Abstract:In the presence of 4-dimethylaminopyridine(DMAP), natural polymer Laminaria(Lam) was reacted with glycidyl methacrylate(GMA) via nucleophilic substitution, resulting in a novel water-soluble biodegradable crosslinker Lam-GMA. Polyacrylamide hydrogels were prepared using the Lam-GMA as crosslinker. Upon the catalysis of lipase, the swelling properties and the degradation behavior of the hydrogels were studied at physiological conditions. As a model macromolecular drug, bovine serum albumin (BSA) was embedded in the hydrogels, and the drug release behavior was studied. Results showed that the conversion of the grafting reaction was high, and the graft ratio could be controlled. More applied amount of crosslinker would lead to a longer degradation time. BSA released slowly from the degraded hydrogels upon the degradation process.
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基金项目:中国博士后科学基金（201104717）
| 作者 | 单位 | |
| 肖云若 | 浙江大学化学工程与生物工程学系，杭州 310027 | 21128075@zju.edu.cn |
| 吴晶军 | 浙江大学化学工程与生物工程学系，杭州 310028 | |
| 赵骞 | 浙江大学化学工程与生物工程学系，杭州 310029 | qianzhao@zju.edu.cn |
引用本文：
肖云若,吴晶军,赵骞.基于改性多糖交联的生物可降解水凝胶的合成及其释药性[J].功能高分子学报,2014,27(2):.
XIAO Yun-ruo,,WU Jing-jun,ZHAO Qian.Synthesis and Drug Release Property of Biodegradable Hydrogels Crosslinked by Modified Polysaccharide[J].Journal of Functional Polymers,2014,27(2):.
肖云若,吴晶军,赵骞.基于改性多糖交联的生物可降解水凝胶的合成及其释药性[J].功能高分子学报,2014,27(2):.
XIAO Yun-ruo,,WU Jing-jun,ZHAO Qian.Synthesis and Drug Release Property of Biodegradable Hydrogels Crosslinked by Modified Polysaccharide[J].Journal of Functional Polymers,2014,27(2):.
