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功能高分子学报:2013,26(2):-

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pH敏感性P(AM-AA-co-C8PhEO10Ac)水凝胶溶胀动力学及其对茶碱的控释

王芳平¹, 张珺瑛², 牟琥珀³, 李晚霞⁴, 王其召⁵, 杜新贞⁶

(1.西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730070;2.西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730071;3.西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730072;4.西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730073;5.西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730074;6.西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730075)

Swelling Kinetics and Theophylline Controlled-Release Properties of pH-Sensitive P(AM-AA-co-C8PhEO10Ac) Hydrogel

WANG Fang-ping¹, ZHANG Jun-ying², MU Hu-po³, LI Wan-xia⁴, WANG Qi-zhao⁵, DU Xin-zhen⁶

(1.Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China;2.Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730071, China;3.Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730072, China;4.Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730073, China;5.Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730074, China;6.Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730075, China)

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中文摘要: 以丙烯酰胺(AM)、丙烯酸(AA)和丙烯酸辛基酚聚氧乙烯醚酯(C8PhEO10Ac)为单体，采用自由基交联共聚法合成了具有pH敏感性的P(AM-AA-co-C8PhEO10Ac)水凝胶。研究了pH、单体配比对凝胶溶胀性能、溶胀动力学和退溶胀动力学的影响。初步探讨了模拟胃液(pH=1.4)、肠液(pH=7.4)中水凝胶对茶碱的控释情况。结果表明:凝胶具有高溶胀、退溶胀速率和良好的pH敏感性等特征；水凝胶的扩散行为在pH=7.4的缓冲溶液中为非Fickian扩散模式；载药凝胶在模拟肠液中对药物的累积释放率明显大于胃液中的累积释放率，其中n(C8PhEO10Ac)∶n(AM)∶n(AA)为1∶20∶30的载药水凝胶对茶碱的累积释放率最大。

中文关键词: 水凝胶 pH敏感溶胀动力学控制释放

Abstract:A pH-sensitive P(AM-AA-co-C8PhEO10Ac) hydrogel was prepared using acrylamide(AM), acrylic(AA) and octylphenyl polyoxyethylene acrylate(C8PhEO10Ac) as monomer by free radical crosslinking polymerization. Effect of pH and monomer ratio on swelling property, swelling and deswelling kinetics of the hydrogels were studied. Theophylline was chosen as a model drug and the controlled-release properties of hydrogels in stimulated gastric fluid (pH=1.4) and intestinal fluid (pH=7.4) were studied. Results showed that the hydrogel had the rapid swelling, deswelling rate and good pH sensitivity. The dynamic swelling behavior of P(AM-AA-co-C8PhEO10Ac) hydrogels belonged to non-Fickian mode in pH=7.4 buffer solutions. The cumulative release rates of drug-loaded hydrogels in stimulated intestinal fluid were higher than those in stimulated gastric fluid. The cumulative release rate of theophylline was the highest when n(C8PhEO10Ac)∶n(AM)∶n(AA) was 1∶20∶30.

keywords: hydrogel pH-sensitivity swelling kinetics controlled release

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基金项目:国家自然科学基金 (21065010，51262028)资助项目

Author Name	Affiliation	E-mail
WANG Fang-ping	Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China	wangfp@nwnu.edu.cn
ZHANG Jun-ying	Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730071, China
MU Hu-po	Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730072, China
LI Wan-xia	Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730073, China
WANG Qi-zhao	Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730074, China
DU Xin-zhen	Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730075, China

引用本文：
王芳平,张珺瑛,牟琥珀,李晚霞,王其召,杜新贞.pH敏感性P(AM-AA-co-C8PhEO10Ac)水凝胶溶胀动力学及其对茶碱的控释[J].功能高分子学报,2013,26(2):.
WANG Fang-ping,ZHANG Jun-ying,MU Hu-po,LI Wan-xia,WANG Qi-zhao,DU Xin-zhen.Swelling Kinetics and Theophylline Controlled-Release Properties of pH-Sensitive P(AM-AA-co-C8PhEO10Ac) Hydrogel[J].Journal of Functional Polymers,2013,26(2):.

作者	单位	E-mail
王芳平	西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730070	wangfp@nwnu.edu.cn
张珺瑛	西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730071
牟琥珀	西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730072
李晚霞	西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730073
王其召	西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730074
杜新贞	西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730075

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