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投稿时间：2016-08-23
投稿时间：2016-08-23
中文摘要: 利用7-（2-羟基乙氧基）-4-甲基香豆素（HEMC）疏水改性透明质酸（HA）制得光敏双亲大分子（HA-HEMC），并通过自组装形成了HA-HEMC胶体粒子。通过核磁共振氢谱和紫外分光光度计确定了HA-HEMC的结构及取代度；采用动态激光光散射、纳米粒度仪和透射电镜等手段对胶体粒子的性质及形貌进行了表征。进一步以HA-HEMC胶体粒子作为颗粒乳化剂稳定油水界面，研究了胶体粒子质量浓度、油相类型、水相pH和盐浓度对胶体粒子乳化性能的影响。结果表明：HA-HEMC可以在选择性溶剂中自组装形成粒径约为236 nm的球形胶体粒子；该胶体粒子能够在较宽的pH范围内（3～11）稳定水包油型乳液且所得乳液有良好的耐盐性；此外，HA-HEMC胶体粒子还能稳定多种油-水体系。
Abstract:By using 7-(2-hydroxyethoxy)-4-methylcoumarin(HEMC) hydrophobic modified hyaluronic acid (HA), photosensitive amphiphilic macromolecules(HA-HEMC) were prepared and HA-HEMC colloidal particles were obtained by self assembly.The structure and substitution degree of HA-HEMC were characterized by hydrogen nuclear magnetic spectra and UV-Vis spectrophotometer.The properties and morphologies of HA-HEMC colloidal particles were characterized by dynamic light scattering,nanoparticle size analyzer and transmission electron microscopy.Additionally,HA-HEMC colloidal particles were applied as the particulate emulsifier to stabilize oil-water interface and the emulsification performance of HA-HEMC colloidal particles in different conditions,such as mass concentration of colloidal particles,oil type,pH value and salt concentration in aqueous phase were investigated.Results showed that HA-HEMC were able to form spherical colloidal particles with the average diameter of 263 nm in selective solvent and HA-HEMC colloidal particles could stable oil-in-water Pickering emulsions in the broader range of pH(3~11) and various concentrations of NaCl.In addition,the colloidal particles were able to stabilize variety of oil-water system.
keywords: hydrophobic modified hyaluronic acid photosensitive amphiphilic macromolecule self-assembled colloidal particle particulate emulsifier
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基金项目:国家自然科学基金（20974041，21174056）；江南大学食品胶体与生物技术教育部重点实验室开发基金（JDSJ2014-07）
引用本文：
诸超,朱叶,魏玮,顾瑶,刘晓亚.香豆素改性透明质酸颗粒乳化剂的制备及应用[J].功能高分子学报,2016,29(4):388-396.
ZHU Chao,ZHU Ye,WEI Wei,GU Yao,LIU Xiao-ya.Preparation and Application of Particulate Emulsifier of Coumarin Modified Hyaluronic Acid[J].Journal of Functional Polymers,2016,29(4):388-396.
诸超,朱叶,魏玮,顾瑶,刘晓亚.香豆素改性透明质酸颗粒乳化剂的制备及应用[J].功能高分子学报,2016,29(4):388-396.
ZHU Chao,ZHU Ye,WEI Wei,GU Yao,LIU Xiao-ya.Preparation and Application of Particulate Emulsifier of Coumarin Modified Hyaluronic Acid[J].Journal of Functional Polymers,2016,29(4):388-396.
