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中文摘要: 利用溶液法预先制备壳聚糖(Cs)-蒙脱土(MMT)复合材料(Cs-MMT),以Cs-MMT、Cs为原料,采用反相悬浮聚合法制得一种新型药物缓释体系阿司匹林-蒙脱土-壳聚糖载药微球(Asp-MMT-Cs)。采用FT-IR、SEM表征了Cs-MMT和Asp-MMT-Cs载药微球的结构及形态;设计正交实验优化了Asp-MMT-Cs载药微球的制备工艺;通过体外释放实验探讨了载药微球在不同模拟释放液中的释药规律。结果表明:所得微球球形度好,粒径分布较均匀;最优工艺制得的载药微球平均粒径为81.20μm,载药量为9.61%,包封率为76.78%。该缓释体系具有pH敏感性,更倾向于在pH较高的磷酸盐缓冲溶液中释放。
Abstract:Cs MMT composites were prepared by solution method, and a new drug sustained release system,Asp MMT Cs microspheres were synthesized by inverse suspension polymerization. FT IR and SEM were applied to characterize the structure and morphology of the obtained Cs MMT composites and Asp MMT Cs microspheres. Orthogonal experiment was designed to optimize the preparation process of the Asp MMT Cs microspheres. And in vitro release experiments were used to determine the release law of the sustained release system. Results show that the obtained microspheres assumed a better sphericity and a more uniformly particle size distribution compared with pure Cs microspheres. The drug loaded microspheres prepared by the optimum conditions exhibit 81.20 μm average particle size, 9.61% drug loading and 76.78% encapsulation rate. Aspirin sustained release system is pH sensitive and tends to show a larger release percentage in the phosphate buffer.
keywords: montmorillonite chitosan aspirin microspheres drug release
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基金项目:
| 作者 | 单位 |
| 杨凤 | 沈阳化工学院材料科学与工程学院 |
| 赵伟 | |
| 张欠 |
| Author Name | Affiliation |
引用本文：
杨凤,赵伟,张欠.阿司匹林-蒙脱土-壳聚糖缓释微球的制备及其体外释放性能[J].功能高分子学报,2010,23(1):29-34.
.[J].Journal of Functional Polymers,2010,23(1):29-34.
杨凤,赵伟,张欠.阿司匹林-蒙脱土-壳聚糖缓释微球的制备及其体外释放性能[J].功能高分子学报,2010,23(1):29-34.
.[J].Journal of Functional Polymers,2010,23(1):29-34.
