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“项链状”聚合物/碳纳米管杂化组装体构建多巴胺传感器
(江南大学)
Fabrication of Dopamine Sensor Based on Necklace-like Polymer/Carbon Nanotubes Nanohybrids
(Jiangnan University)
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投稿时间:2018-07-12    修订日期:2018-08-13
中文摘要: 以7-(4-乙烯基苄氧基)-4-甲基香豆素、丙烯酸异辛酯及丙烯酸为功能单体合成了一种双亲性无规共聚物(PAVE)。随后将PAVE与碳纳米管(CNTs)在选择性溶剂DMF/H2O共组装,得到聚合物/碳纳米管杂化组装体PAVE/CNTs,利用透射电子显微镜对PAVE/CNTs的形貌进行表征。接着将PAVE/CNTs修饰在玻碳电极表面,紫外光交联固化后制备得到复合传感涂层,并用于检测多巴胺,利用扫描电子显微镜与电化学工作站分别对涂层形貌与传感性能进行表征与测试。结果表明:PAVE与CNTs共组装形成了以PAVE纳米粒子为“珠”、CNTs为“线”的“项链状”杂化组装体,传感涂层为交错互穿的“网络状”复合结构,所构建的传感器对多巴胺具有较宽的检测范围(4~90 μmol/L)与低检测下限(0.24 μmol/L),并具有优异的选择性与稳定性。
Abstract:A novel kind of nanohybrids with a “necklace-like” morphology was prepared via one-step co-assembly of amphiphilic random copolymer with multi-walled carbon nanotubes (CNTs) and successfully employed as effective electrode material to construct an electrochemical sensor for highly sensitive dopamine (DA) determination. A photo-crosslinkable amphiphilic copolymer poly(acrylic acid-co-(7-(4-vinylbenzyloxy)-4-methyl coumarin)-co-ethylhexyl acrylate) (PAVE) was synthesized firstly via one-step free radical polymerization. The chemical structure of resultant PAVE copolymer was verified by Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy (1H-NMR). Then PAVE copolymer was co-assembled with CNTs in aqueous solution, generating hybrid assembly PAVE-CNTs. As characterized by transmission electron microscopy (TEM), the PAVE-CNTs showed “necklace-like” morphology with PAVE nanoparticles as the beads and CNTs as the long axis. Thanks to the enhanced binding interaction between PAVE copolymers and CNTs sidewalls by photo-crosslinking as well as the steric exclusion among PAVE-CNTs nanohybrids,the obtained nanohybrids showed good dispersion stability in aqueous solution with preserving the intrinsic structural properties of CNTs. For sensing application, PAVE-CNTs were used as electrode material to modify glassy carbon electrode (GCE) surface. A robust composite film with cross-conjugated network was formed on the electrode surface and an electrochemical sensor was developed. Owing to the large surface area of PAVE-CNTs nanohybrids based sensor film and superior electrical conductivity of this long conducting nanohybrids, the as-prepared DA sensor showed a significantly wide linear detection range (4 ~ 90 μmol/L) and low detection limit (0.24 μmol/L) for DA detection. The sensor also showed excellent anti-interference ability, which was successfully applied in determining DA in real urine samples, demonstrating a promising feature for practical application in biomedical diagnosis. This rationally integrated hierarchical nano-micro architecture, which may serve as a versatile platform for immobilizing functional factors, possesses significant advantages including increase in mechanical stability, higher specific surface area, larger loading capacity of functional factors and better electrical conductivity comparing with traditional cloddy polymer/CNTs nanocomposites, demonstrating great application potential in a wide range of fields like biosensors and other microelectronic devices.
文章编号:20180712001     中图分类号:O63    文献标志码:
基金项目:江苏省研究生科研创新计划项目(KYCX17_1428)
作者单位地址
许升 江南大学 江苏省无锡市蠡湖大道1800号化学与材料工程学院
徐振宇 江南大学 
王乾坤 江南大学 
王满 江南大学 
张雨珩 江南大学 
陈彦儒 江南大学 
刘晓亚* 江南大学 滨湖区蠡湖大道1800号江南大学化学与材料工程学院
Author NameAffiliationAddress
XU Sheng Jiangnan University 江苏省无锡市蠡湖大道1800号化学与材料工程学院
XU Zhenyu Jiangnan University 
WANG Qiankun Jiangnan University 
WANG Man Jiangnan University 
ZHANG Yuheng Jiangnan University 
CHEN Yanru Jiangnan University 
LIU Xiaoya Jiangnan University 滨湖区蠡湖大道1800号江南大学化学与材料工程学院
引用本文:
许升,徐振宇,王乾坤,王满,张雨珩,陈彦儒,刘晓亚.“项链状”聚合物/碳纳米管杂化组装体构建多巴胺传感器[J].功能高分子学报,DOI:10.14133/j.cnki.1008-9357.20180712001.
XU Sheng,XU Zhenyu,WANG Qiankun,WANG Man,ZHANG Yuheng,CHEN Yanru,LIU Xiaoya.Fabrication of Dopamine Sensor Based on Necklace-like Polymer/Carbon Nanotubes Nanohybrids[J].Journal of Functional Polymers,DOI:10.14133/j.cnki.1008-9357.20180712001.