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投稿时间：2016-05-08
投稿时间：2016-05-08
中文摘要: 首先以聚乙二醇单甲醚(mPEG-OH)为单体,采用经典的盖布瑞尔伯胺合成法合成了端氨基聚乙二醇单甲醚(mPEG-NH2); 然后以mPEG-NH2为引发剂,S-苄基L-半胱氨酸N-羧酸内酸酐(BCys-NCA)为原料,通过N-羧酸内酸酐(NCA)开环聚合反应和液氨/钠处理脱除侧链上的保护基团,合成了两亲性嵌段共聚物甲氧基聚乙二醇-b-聚L-半胱氨酸(mPEG-b-PCys)。采用傅里叶变换红外光谱、核磁共振氢谱对聚合物的结构和组成进行了表征。结果表明:成功制备了侧链具有还原性巯基的两亲性嵌段共聚物mPEG-b-PCys,并且其聚合度可控性良好。
Abstract:Amine-terminated mPEG (mPEG-NH2) was first synthesized by Gabriel method using mPEG-OH as the monomer.Methoxy poly(ethylene glycol)-b-poly(L-cysteine) (mPEG-b-PCys) amphiphilic block copolymers were further synthesized by ring opening copolymerization of S-benzyl L-cysteine N-carboxyanhydride (BCys-NCA) initiated with the amine terminated mPEG and followed by the removal of the protected groups using liquid NH3/Na.The structures of the polymers were characterized by Nuclear Magnetic Resonance spectroscopy (1H-NMR) and Fourier Transform Infrared spectroscopy (FT-IR).Results showed that the amphiphilic block copolymers containing active thiol groups were synthesized successfully,and the degree of polymerization was controllable.
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基金项目:
| 作者 | 单位 | |
| 陈洋 | 华东理工大学材料科学与工程学院, 上海 200237 | |
| 肖艳 | 华东理工大学材料科学与工程学院, 上海 200237 | yxiao@ecust.edu.cn |
引用本文：
陈洋,肖艳.甲氧基聚乙二醇-b-聚L-半胱氨酸两亲性嵌段共聚物的合成与表征[J].功能高分子学报,2016,29(2):188-192.
CHEN Yang,XIAO Yan.Synthesis and Characterization of Poly(ethylene glycol)-b-Poly(L-cysteine) Block Copolymer[J].Journal of Functional Polymers,2016,29(2):188-192.
陈洋,肖艳.甲氧基聚乙二醇-b-聚L-半胱氨酸两亲性嵌段共聚物的合成与表征[J].功能高分子学报,2016,29(2):188-192.
CHEN Yang,XIAO Yan.Synthesis and Characterization of Poly(ethylene glycol)-b-Poly(L-cysteine) Block Copolymer[J].Journal of Functional Polymers,2016,29(2):188-192.
